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KMID : 0928320070070010001
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Korean Journal of Health Promotion and Disease Prevention
2007 Volume.7 No. 1 p.1 ~ p.7
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Exercise physiologic mechanisms related to effective exercise prescription in type 2 diabetes mellitus
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Kang Hyun-Joo
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Abstract
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Insulin and exercise are the most physiologically relevant stimulators of glucose transport in type 2 diabetes mellitus. Two separate pools of glucose transporters in muscle, with one pool being susceptible to translocation by the action of insulin but not muscle contraction, and the other responding to the signal generated by contractions but not insulin. Type 2 diabetes patients can increase rates of muscle glucose uptake with exercise, because the muscle is able to bypass in the insulin signaling molecules and effectively activate the exercise-specific signaling mechanism.
This effect of exercise is similar to the action of insulin on glucose uptake, and the mechanism through which both stimuli increase skeletal muscle glucose uptake involves the translocation of GLUT-4 glucose transporters to the plasma membrane and transverse tubules. Thus the exercise-stimulated physiologic mechanisms resulting in increased muscle glucose transport may be important as an alternative pathway to states of insulin resistances. This review provides the evidence and possible mechanisms by which exercise produces these benefits, and gives a brief review of effective exercise and special considerations. (Korean J Health Promot Dis Prev 2007 ; 7(1) : 1~7)
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